Skin Pigmentation Treatment, melanin, together with skin shades in varying hues, is extremely variable for a range of reasons like genetics, exposure to UV rays, and some medicines. Just imagine, all such skin diseases, granting pigmentary irregularities tamper with the patients’ physical appearance, psyche, and social behaviors. Hyperpigmentation is when there is too much pigment in the tissues whereas hyperpigmentation constitutes less color being deposited. Dermatological cases presenting with the usual pigmentary disorders include albinism, melasma, vitiligo, Addison’s disease, and post-inflammatory skin pigmentation after eczema, acne vulgaris, and drugs. Pigmentation disorders’ therapeutic treatments include anti-inflammatory agents, antioxidants, and tyrosinase inhibitors, which stop melanin production. Skin discolorations can be treated using medications-termed as potions and beauty products, both orally and topically-with consultation from a dermatologist. This review article intends to cover all possible pigmentation disorders, their causes, and their remedies, together with 25 plants, 4 marine organisms, and 17 topically and orally tested drugs to date for the skin.